I ran it on a RPi4 years ago, but it didn’t perform well enough. It performs fine on an old laptop, but not so much in a Pi from my experience. Can’t speak to the RPi5, though.

There are unfortunately still useful things that only work on Windows, which is why I still begrudgingly dual boot. I like the idea of ReactOS, but development is slow-going and it’s still only alpha quality at the moment.